What is NAD+?
NAD+ is a coenzyme also known as nicotinamide adenine dinucleotide that enables the transfer of energy inside the mitochondria of the cells. NAD+ is probably as important as oxygen to make cells work. It is the “fuel” for the mitochondria inside each cell. NAD+ levels begin to decline after age 30, and in response to unhealthy lifestyle, diet, use of drugs or alcohol, stress, toxins, or a host of other factors. Levels are particularly low in neurodegenerative conditions such as Parkinson’s, MS, or Alzheimer’s.
What Does NAD+ Do?
NAD+ multiple functions. Primarily, it is involved with DNA repair, cellular function energy production, and promoting cell health. It is especially important for tissue repair, neuro-regeneration, longevity, and inflammation.
What Factors are to Blame for NAD+Deficiencies?
DEGENERATIVE DISEASES: Research shows NAD+ deficiencies may trigger a host of metabolic and degenerative diseases—including Alzheimer’s, amyotrophic lateral sclerosis (ALS), Parkinson’s, and cardiometabolic disease. Two clinical trials have tested IV and oral NAD+ in Parkinson’s patients. There was an 80% positive response rate, with 20% rating their improvement as “very good.” The effect was strongest amongst patients who were younger and more recently diagnosed. More research is underway.
2. STRESS: The American Psychological Association links chronic stress to the six leading
causes of death: heart disease, cancer, lung ailments, accidents, cirrhosis of the liver and
suicide. The physiologic consequences of stress include oxidative stress, which can be tested
for with lab tests. High levels of oxidative stress are an indication for NAD+
supplementation.
3. DIET / ALCOHOL / DRUGS: The body doesn’t make NAD+ unless you consume ample
Vitamin B3 (niacinamide) or its precursor tryptophan. The modern-day diet high in sugar,
refined flour and unhealthy fats deplete NAD+. In addition, the use of alcohol and drugs are
strong contributors to NAD+ depletion. IV NAD+ has long been used to detoxify patients
from alcohol, opiates, tranquilizers and stimulants. In my clinical experience, it helps greatly
reduce withdrawal symptoms, often eliminating drug/alcohol cravings and, most
importantly, restores mental clarity.
4. INFLAMMATION: Inflammation has become a major issue and contributing factor in the
majority of chronic conditions. Simply put, inflammation is your immune system’s response to
stress – whether it be from injury, diet, emotions, lifestyle, or environment. Unfortunately, the
immune system is prone to overreaction and consumes large amounts of NAD+. Further,
inflammation can lead to tissue damage ranging from arthritis to heart disease. Restoring
NAD+ levels calms the immune system and repairs the damage.
What are the biggest benefits of NAD+ therapy?
BRAIN FUNCTION: One of the most impacted organs from NAD+ deficiency is the brain. NAD+ helps replenish the supply of neurotransmitters and improve cognitive functioning. Subjectively, patients report feeling clearer. Vision and awareness are sharpened. Elderly patients often report tackling paperwork like estate planning and banking with renewed motivation and clarity. NAD+ has been shown to be effective with cases of brain fog, cognitive impairment, brain function “chemo brain”.
ANTI-AGING: Because of its key role in cellular energy and DNA repair, NAD plays a critical role in anti-aging and longevity. A research review reported “upregulation of NAD metabolism, including dietary supplementation with NAD precursors, has been shown to prevent the decline of NAD and exhibits beneficial effects against aging and aging-associated diseases. In addition, many studies have demonstrated that genetic and/or nutritional activation of NAD metabolism can extend the lifespan of diverse organisms.”
How do I try NAD+ therapy?
The best results are achieved with intravenous NAD+ given repeatedly with other B vitamin and anti-oxidants. Dr. Oberg’s proprietary combination formula is superior to most options offered by other clinics. Please ask what a personalized protocol for your concerns would look like. On average, 5 or 10 infusions are given on a twice/week schedule. Often a series of 5 is repeated every 6-12 months for maintenance. Dose is titrated to patient tolerance. starting at low dose $399 per infusion, up to high doses for $699 with a 10% discount when purchased in packs of 5 or 10.
It should also be taken as a daily dietary supplement in the form of nicotinamide riboside 500mg per day. Intermittent fasting, moderate intake of wine, and resveratrol also promote NAD+.